Keywords
platelets
sepsis
How to Cite
Abstract
Introduction: Sepsis is one of the main causes for admission of patients in intensive care units (ICUs). In critical patients, the most common hematologic disorder and powerful indicator expressing a global physiological disorder is thrombocytopenia. In these conditions, platelet size, which can be detected by the mean platelet volume (MPV), may be altered. Objectives: To evaluate the variation in the platelet count and MPV during the first 72 hours of hospitalization and its association with mortality, in patients who were hospitalized in ICUs with a diagnosis of sepsis or septic shock of any etiology. Materials and methods: Measurements of the MPV and platelet counts were analyzed in patients hospitalized in ICUs, divided into two groups: septic and non-septic controls, at admission and 24, 48, 72 hours after admission. Results: The mean platelet count of septic patients was lower than that of a patient with unrelated diagnosis, and the MPV was significantly higher after 24 hours and became more evident as the days of hospitalization increased. The MPV of septic patients who died was higher than that of those who survived after 24 hours and the platelet count was lower than that of those who survived after 72 hours. In addition, their MPV was higher than 10.0 fL after 24 hours of hospitalization. Conclusions: Validating the MPV as a sepsis prognostic biomarker would mean having a practical and quickly available tool.
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