Efecto de la inhalación de las partículas aéreas de la Ciudad de Buenos Aires: alteraciones histomorfológicas, metabólicas y bioquímicas a nivel pulmonar y extrapulmonar en ratones jóvenes y adultos mayores

Abstract

Introduction: Numerous studies have shown that air pollution is consistently associated with adverse health effects. Epidemiological data have specifically shown an association between the exposure to air particulate matter (PM) and an increase in cardiorespiratory morbidity/mortality. Smaller particles can be translocated from the lungs into the circulation and affect extrapulmonary organs such as the heart and liver. However, PM does not equally impact all the population, since the effects of MP on health may be influenced by age. Objective: to study in vivo the biological mechanisms by which Buenos Aires Urban Air Particles (UAP-BA) could induce adverse effects on the respiratory system and extrapulmonary organs of young and adult mice.
Materials and Methods: young (3 months old) and adult (9 months old) BALB/c mice were exposed to UAP-BA or ROFA (surrogate of airborne contamination) by intranasal instillation. In the lung, heart and liver, the biological response was assessed metabolically (oxidative and inflammatory parameters), biochemically (serum biomarkers), and histomorphologically at 3, 24 and 48 h post-instillation. Results: both types of PM caused local and systemic inflammatory response. Histologically, we observed a reduction of the alveolar area in the lung, heart epicardial inflammation, and liver inflammation and steatosis with an increase in the levels of serum transaminases in both age groups.
Conclusions: we showed in a murine experimental
model that UAP-BA altered not only the respiratory system but also extrapulmonary organs such as the heart and liver. Therefore, we hypothesized that UAP-BA could potentially induce similar adverse biological effects on young and