Keywords
flavivirus
severe dengue
epidemiology
leukopenia
thrombocytopenia
transaminases
How to Cite
Abstract
During March and April 2023, there was a marked increase in the number of reported dengue cases in several cities of Argentina. In this context, we collected and analyzed the results obtained from 813 patients with suspected dengue who attended the Julio Méndez Sanatorium (Buenos Aires), coming from the Buenos Aires metropolitan area. Objectives: i) To validate the rapid immunochromatographic test for the NS1 antigen used; ii) To establish the positivity ratio (PR) and circulating serotype; and iii) To analyze leukocyte, platelet and transaminase counts in patients diagnosed with dengue. Results: The rapid immunochromatographic test for NS1 antigen used was validated in the first 100 patients analyzed, comparing it with the ELISA method for NS1 from the Ricardo Gutierrez National Hospital Laboratory (Buenos Aires). The agreement between both tests was 99%. The PR for dengue infection in March was 61.8%, whereas that in April was 62.2%. In 90.6% of the patients, the prevalent circulating serotype was dengue type 2 (DEN-2). Of the 432 patients with laboratoryconfirmed dengue, 142 (32.8%) had normal leukocyte counts, 251 (58.1%) had moderate leukopenia, and 39 (9.1%) had severe leukopenia. Regarding the platelet count, 260 (60%) showed normal platelets, 168 (39%) had moderate thrombocytopenia and 4 (1%) showed severe thrombocytopenia. Transaminase values were normal in 251 cases (58.2%) and high in 181 (41.8%). Conclusions: In the patients analyzed, the prevalence of moderate and severe leukopenia was higher than that of thrombocytopenia of the same intensity.
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