Keywords
Metabolic Syndrome
Obesity
Diabetes
How to Cite
Abstract
Introduction: The absolute leukocyte telomere length (aLTL) is considered a marker of cellular aging and could be a biomarker of the prevalence and progression of metabolic diseases. Objective: Our objective was to determine the aLTL by qPCR, in a cross-sectional study, and assess its association with biochemical- clinical variables and the different components of Metabolic Syndrome (MS). On the other hand, two prospective controlled studies were performed to evaluate changes in aLTL in individuals with type 2 diabetes (T2D) undergoing antidiabetic treatment, and obese patients after bariatric surgery (BS). Results: We observed a decrease in the aLTL with the increase in the number of components of the MS (0, 1, or 2 components or MS; p<0.001), observing differences between groups 0 vs 1 (p=0.010), 0 vs 2 (p<0.001) and 0 vs SM (p<0.001). In T2D, a variation was found in aLTL after antidiabetic treatment. However, we found a significant positive association between the variation in aLTL and the dose of metformin used (p=0.048). In obese patients, aLTL significantly increased 6 months after BS (p=0.013), which is probably due to the improvement in the metabolic status and the decrease in the inflammation status. This increase was observed mainly at the expense of morbidly obese patients (p=0.022), in whom the greatest increases in aLTL were associated with greater decreases in PCR as a marker of inflammation (p=0.024).
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